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个人简介



张仲徽.jpg

  • 性别：男
  • 职称：研究员
  • 学历：博士研究生
  • 学科：植物学
个人简历

张钟徽，博士，研究员，博士生导师。2017年作为海外高层次青年拔尖人才引进并入职纽约国际967地址。近年来主要从事植物发育与逆境胁迫响应相关的表观遗传调控机理研究，在Nature Plants、Plant Cell、PNAS、JIPB、eLife、Current Opinion in Plant Biology等国际权威期刊上发表SCI论文32篇；现主持承担国家自然科学基金面上项目、广东省自然科学杰出青年基金项目；获得2013年教育部自然科学奖一等奖和2014年国家自然科学奖二等奖。现任广东省植物生理学会理事、广东省遗传学会理事、广东省植物病理学会理事、植物生理学报编委。


教育经历
1999 - 2003年 中山大学 生物科学 理学学士 2003 - 2009年 中山大学 植物学 理学博士 （2004 – 2009年 中科院遗传与发育生物学研究所 客座学习和研究）
工作经历
2009 - 2011年 中科院遗传与发育生物学研究所 项目聘用研究人员 2011 - 2016年 美国德州农工大学（Texas A&M University）生化系 博士后研究员 2017 – 至今 纽约国际967地址 研究员
研究方向
（1） 植物逆境胁迫响应的表观遗传调控 植物在生长发育过程中常常会遭遇各种生物和非生物逆境胁迫等不利因素的影响，固着生长的植物不能主动趋避，只能依靠自身一些胁迫响应机制来实现防御，表观遗传调控在其中起到了非常重要的作用。本实验室重点关注并致力于解析表观遗传修饰相关基因在逆境胁迫响应过程中的功能和调控机理，挖掘与植物逆境胁迫应答相关的表观遗传调控因子，最终为现代分子育种技术选育农作物抗逆新品种提供新思路。 （2） 植物miRNA生物合成与代谢的调控机理 植物细胞内miRNA生物合成的调控是一个多层面的精细过程，例如转录、转录后剪接、pri-miRNA的剪切、miRNA的成熟、RNA的稳定性、主要生物合成元件蛋白的稳定性、miRNA的时空分布等多个环节都可能影响miRNA的含量及其对下游靶基因的调控。本实验室主要通过遗传学、生物信息学、细胞生物学、生物化学和分子生物学等方面的技术手段，找寻参与miRNA途径的新调控因子，深入阐释miRNA合成与代谢过程的调控机理。
讲授课程
《遗传学》 本科生 必修课 《遗传学实验》 本科生 必修课 《高级植物生物学》 研究生 必修课
承担课题
国家自然基金面上项目(2018-2021) 国家自然基金面上项目(2022-2025) 广东省自然科学杰出青年基金（2019-2023）
论文专著

论文专著(#第一作者，*通讯作者)

1. Bai, H#, Dai, Y#, Fan, P#, Zhou, Y, Wang, X, Chen, J, Jiao, Y, Du, C, Huang, Z, Xie, Y, Guo, X, Lang, X, Ling, Y, Deng, Y, Liu, Q*, He, S*, Zhang, Z*. The METHYLTRANSFERASE B–SERRATE interaction mediates the reciprocal regulation of microRNA biogenesis and RNA m6A modification. Journal of Integrative Plant Biology, 2024, 66: 2613–2631.

2. Zhong, S#, Li, X#, Li, C#, Bai, H, Chen, J, Gan, L, Zhu, J, Oh, T, Yan, X, Zhu, J, Li, N, Koiwa, H, Meek, T, Peng, X, Yu, B, Zhang, Z*, Zhang, X*. SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis. Nature Cell Biology, 2024, 26: 2129–2143.

3. Gan, Y#, Wang, L, Liu, G, Guo, X, Zhou, Y, Chang, K, Zhang, Z, Yan, F, Liu, Q, Chen, B. Transposable Elements Contribute to the Regulation of Long Noncoding RNAs in Drosophila melanogaster. Insects, 2024, 15(12).

4. Xia, S#, Chen, Y, Lai, J, Zhang, Z, Yang, C, Han, D. Functional characterization of protein SUMOylation in the miRNA transcription regulation during heat stress in Arabidopsis. Plant Genome, 2024, 17(4): e20511.

5. Yu, Z#, Wang, J#, Zhang, C, Zhan, Q, Shi, L, Song, B, Han, D, Jiang, J, Huang, J, Ou, X, Zhang, Z, Lai, J, Li, Q Q, Yang, C. SIZ1-mediated SUMOylation of CPSF100 promotes plant thermomorphogenesis by controlling alternative polyadenylation. Molecular Plant, 2024, 17(9):1392-1406.

6. Du, C#, Liu, M#, Yan, Y#, Guo, X, Cao, X, Jiao, Y, Zheng, J, Ma, Y, Xie, Y, Li, H, Yang, C, Gao, C, Zhao, Q*, Zhang, Z*. The U-Box E3 Ubiquitin Ligase PUB35 Negatively Regulates ABA Signaling through AFP1-mediated Degradation of ABI5. Plant Cell, 2024, 36: 3277-3297.

7. Li, H#, Li, T#, Li, Y#, Bai, H, Dai, Y, Liao, Y, Wei, J, Shen, W, Zheng, B, Zhang, Z*, Gao, C *. The plant FYVE domain-containing protein FREE1 associates with microprocessor components to repress miRNA greater biogenesis. EMBO Reports, 2023, 24(1).

8. Jiang, J#, Ou, X#, Han, D, He, Z, Liu, S, Mao, N, Zhang, Z, Peng, C, Lai, J*, Yang, C*. A diRNA-protein scaffold module mediates SMC5/6 recruitment in plant DNA repair. Plant Cell , 2022, 34(10): 3899-3914.

9. Li, H#, Wei, J, Liao, Y, Cheng, X, Yang, S, Zhuang, X, Zhang, Z, Shen, W, Gao, C *. MLKs kinases phosphorylate the ESCRT component FREE1 to suppress abscisic acid sensitivity of seedling establishment. Plant, Cell & Environment , 2022, 45(7): 2004-2018.

10. Du, C#, Bai, H, Chen, J, Wang, J, Wang, Z, Zhang, Z*. Alternative Splicing Regulation of Glycine-Rich Proteins via Target of Rapamycin-Reactive Oxygen Species Pathway in Arabidopsis Seedlings Upon Glucose Stress. Frontiers in Plant Science, 2022, 13.

11. Zhu, C#, Liu, J, Zhao, J, Liu, T, Chen, Y, Wang, C, Zhang, Z, Guo, H, Duan, C*. A fungal effector suppresses the nuclear export of AGO1–miRNA complex to promote infection in plants. Proc Natl Acad Sci U S A., 119 (12): e2114583119.

12. Xie, Y#, Gu, Y, Shi, G, He, J, Hu, W, Zhang, Z*. Genome-Wide Identification and Expression Analysis of Pseudouridine Synthase Family in Arabidopsis and Maize.  International Journal of Molecular Sciences, 2022, 23(5), 2680.

13. Chen, Z#, Zhao, J, Chen, Q, Zhang, Z, Li, J, Guo, Z, Xie, Q*, Ding, S*, Guo, H*. DNA Geminivirus Infection Induces an Imprinted E3 Ligase Gene to Epigenetically Activate Viral Gene Transcription. Plant Cell, 2020, 32(10):3256-72.

14. Xiong, F, Duan, C, Liu, H, Wu, J, Zhang, Z, Li, S, Zhang, Y*. Arabidopsis KETCH1 Is Critical for the Nuclear Accumulation of Ribosomal Proteins and Gametogenesis. Plant Cell, 2020, 32(4):1270-84.

15. Zhang, Z#, Hu, F#, Sung, M, Shu, C, Castillo-González, C, Koiwa, H, Tang, G, Dickman, M, Li, P*, Zhang, X*. RISC-Interacting Clearing 3’- 5’ Exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis. Elife, 2017: e24466.

16. Guo, X, Ma, Z, Zhang, Z, Cheng, L, Zhang, X*, Li, T**. Small RNA-Sequencing Links Physiological Changes and RdDM Process to Vegetative-to-Floral Transition in Apple. Frontiers in Plant Science, 2017, 8: 873.

17. Zhang, Z#, Guo, X#, Ge, C#, Ma, Z, Jiang, M, Li, T, Koiwa, H, Yang, SW, Zhang, X*. KETCH1 Imports HYL1 to Nucleus for miRNA Biogenesis in Arabidopsis. Proc Natl Acad Sci U S A., 114 (15), 4011-4016.

18. Zhang, Z#, Liu, X#, Guo, X, Wang, X*, Zhang, X*. Arabidopsis AGO3 predominantly recruits 24-nt small RNAs to regulate epigenetic silencing. Nature Plants, 2016, 2: 16049.

19. Zhou, Y#, Honda, M, Zhu, H, Zhang, Z, Guo, X, Li, T, Li, Z, Peng, X, Nakajima, K, Duan, L, et al.. Spatiotemporal sequestration of miR165/166 by Arabidopsis Argonaute10 promotes shoot apical meristem maintenance. Cell Reports, 2015, 10(11): 1819--1827.

20. Yang, L#, Fang, Y, An, C, Dong, L, Zhang, Z, Chen, H, Xie, Q, Guo, H*. C2-mediated decrease in DNA methylation, accumulation of siRNAs, and increase in Expression for genes involved in defense pathways in plants infected with beet severe curly top virus. Plant Journal, 2013, 73(6): 910--917.

21. Zhang, Z, Zhang, X*. Argonautes compete for miR165/166 to regulate shoot apical meristem development. Current Opinion in Plant Biology, 15(6): 652-658.

22. Wu, H#, Zhang, Z#, Wang, J#, Oh, D#, Dassanayake, M#, Liu, B#, Huang, Q#, Sun, H, Xia, R, Wu, Y, et al.. Insights into salt tolerance from the genome of Thellungiella salsuginea. Proc Natl Acad Sci U S A., 2012, 109(30): 12219-12224.

23. Cui, F#, Liu, L, Zhao, Q, Zhang, Z, Li, Q, Lin, B, Wu, Y, Tang, S, Xie, Q*. Arabidopsis ubiquitin conjugase UBC32 is an ERAD component that functions in brassinosteroid-mediated salt stress tolerance. Plant Cell, 2012, 24(1): 233--244.

24. Zhang, Z#, Chen, H, Huang, X, Xia, R, Zhao, Q, Lai, J, Teng, K, Li, Y, Liang, L, Du, Q, et al.. BSCTV C2 attenuates the degradation of SAMDC1 to suppress DNA methylation-mediated gene silencing in Arabidopsis. Plant Cell, 2011, 23(1): 273-288.

25. Teng, K#, Chen, H, Lai, J, Zhang, Z, Fang, Y, Xia, R, Zhou, X, Guo, H, Xie, Q*. Involvement of C4 Protein of Beet Severe Curly Top Virus (Family Geminiviridae) in Virus Movement. PLoS ONE, 5(6): e11280.

26. Chen, H#, Zhang, Z, Teng, K, Lai, J, Zhang, Y, Huang, Y, Li, Y, Liang, L, Wang, Y, Chu, C, Guo, H, Xie, Q*. Up-regulation of LSB1 / GDU3 affects geminivirus infection by activating the salicylic acid pathway. Plant Journal, 62(1): 12-23.

27. Liu, L#, Zhang, Y, Tang, S, Zhao, Q, Zhang, Z, Zhang, H, Dong, L, Guo, H, Xie, Q*. An efficient system to detect protein ubiquitination by agroinfiltration in Nicotiana benthamiana. Plant Journal, 2010, 61(5): 893-903.

28. Wang, W#, Wu, Y, Li, Y, Xie, J, Zhang, Z, Deng, Z, Zhang, Y, Yang, C, Lai, J, Zhang, H, Bao, H, Tang, S, et al.. A large insert Thellungiella halophila BIBAC library for genomics and identification of stress tolerance genes. Plant Molecular Biology, 72(1-2): 91-99.

29. Lai, J#, Chen, H, Teng, K, Zhao, Q, Zhang, Z, Li, Y, Liang, L, Xia, R, Wu, Y, Guo, H, Xie, Q*. RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle. Plant Journal, 2009, 57(5): 905-917.

30. Zheng, N#, de Jesus Perez, J, Zhang, Z, Dominguez, E, Garcia, JA, Xie, Q*. Specific and efficient cleavage of fusion proteins by recombinant plum pox virus NIa protease. Protein Expression and Purification, 2008, 57(2): 153-162.

31. Du, Q#, Duan, C#, Zhang, Z#, Fang, Y, Fang, R, Xie, Q, Guo, H*. DCL4 Targets Cucumber Mosaic Virus Satellite RNA at Novel Secondary Structures. Journal of Virology, 81(17): 9142-9151.

32. Chu, Z#, Chen, H, Zhang, Y, Zhang, Z, Zheng, N, Yin, B, Yan, H, Zhu, L, Zhao, X, Yuan, M, Zhang, X, Xie, Q*. Knockout of the AtCESA2 gene affects microtubule orientation and causes abnormal cell expansion in Arabidopsis. Plant Physiology, 2007, 143(1): 213-224.


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