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个人简介



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  • 性别：男
  • 职称：研究员
  • 学历：博士
  • 学科：生物物理学
个人简历

周小明，湖南邵阳人，研究员，博士生导师。

课题组主页：https://www.x-mol.com/groups/zhoulab2020

基于多学科背景，以交叉技术的角度开展生物、医学分子诊断方法和技术的开发和应用研究工作。研究内容主要聚焦于：“定性和定量核酸检测方法的研究及其在重大疾病核酸标志物、病原微生物的检测应用”。研究成果在PNAS, Nature Protocols, Nature Communications, JACS, Angewandte Chemie, Nano Letters, ACS Nano, Chemical Society Reviews, Analytical Chemistry等期刊发表研究论文。获Annual Review of Analytical Chemistry、ACS Nano等刊物邀请撰写综述论文。申请国家发明专利 20 项，目前已获得授权 14 项。获国家万人计划青年拔尖人才，广东省杰出青年科学基金、广东省特支计划（科技创新青年拔尖人才）、广东省优秀青年教师基金、广州市珠江科技新星等人才项目资助。主持国家自然科学基金委“未来生物技术”原创探索重点项目、重大研究计划培育项目、面上等项目。前期研究成果获教育部自然科学二等奖。

获聘《激光生物学报》常务编委、《分析测试学报》青年编委、中国光学学会生物医学光子学专委、中国生物医学工程学会生物医学光子学青委、广东省医学生物技术教指委，广东省生物物理学会理事，广东省生物医学工程学会理事。 担任《Nature Biomedical Engineering》, 《Nature Communications》, 《Nucleic Acids Research》, 《Science Advances》, 《JACS》 《Advanced Materials》, 《ACS Nano》,《Clinical Chemistry》, 《Analytical Chemistry》, 《Advanced Science》, 《Biotechnology and Bioengineering》等生物、化学、材料、环境、医学领域权威刊物评审专家。


教育经历
2014.9—2015.6，武汉大学，化学与分子科学学院，教育部青年骨干访问学者 2005.9—2010.7， 生物物理学博士，纽约国际967上网导航，博士（生物物理） 2001.9—2005.7， 生物科学学士，湖南文理学院，学士（生物科学）
工作经历
2018.04-至今： 纽约国际967上网导航，纽约国际967地址，分子生物医学实验室（建立者），研究员 2016.12—2018.04： 纽约国际967上网导航，生物光子学研究院，激光生命科学教育部重点实验室，研究员 2015.6—2016.12： 纽约国际967上网导航，生物光子学研究院，激光生命科学教育部重点实验室，特聘研究员 2013.1—2015.6： 纽约国际967上网导航，生物光子学研究院，激光生命科学教育部重点实验室，副研究员 2010.7—2012.12： 纽约国际967上网导航，生物光子学研究院，激光生命科学教育部重点实验室，讲师
研究方向
基于多学科背景，以交叉技术的角度开展基因检测中的“样品处理、探针设计与合成、基因扩增方法、传感器构建及其在疾病诊断、动植物病原防疫、食源性有害微生物的分子诊断应用”研究工作。
讲授课程
生物医学工程概论，本科生 生物制药，本科生 分子细胞生物学，研究生 学科前沿进展，研究生
承担课题
正（曾）承担纵向课题： 1. 广东省自然科学基金省企联合基金，发展集提取、RPA快速扩增、及CRISPR识别一体化的侧向层析核酸检测系统及应用，2022.01-2024.12，20万元，主持。 2. 国家自然科学基金：“未来生物技术”原创探索项目，2022.01-2024.12，300万元，主持。 3. 国家万人计划青年拔尖人才项目，160万元，主持。 4. 国家自然科学基金-重大研究计划（肿瘤演进与诊疗的分子功能可视化研究）：基于CRISPR/Cas识别原理的纸芯片研究及其在肿瘤基因突变、甲基化可视化检测的应用，2020.01-2022.12，83万元，主持 5. 湖北省重点研发计划项目：适宜基层使用的一体化多通道新冠病毒核酸快速检测技术的研发，2020.12-2022.12，200万元，与湖北省疾控共主持。 6. 国家自然科学基金-面上项目：具有聚合活性三联吡啶钌探针的构建及其在体外与原位分子诊断中的应用, 2019.1-2022.12，66万元，主持 7. 国家自然科学基金-面上项目：适配体靶向与转运的功能化核酸探针构建及端粒酶活性调控与分析，2015.1-2018.12，85万元，主持 8. 国家自然科学基金-青年项目：基于单分子荧光光谱与核酸探针的均相生物传感新方法与技术研究，2012.1-2014.12，23万元，主持 9. 广东省自然科学-杰出青年基金：重要病原微生物的核酸分子诊断新策略及新技术研究，2014.10-2018.10，100万元，主持 10. 广东省特支计划：科技创新青年拔尖人才项目，2015.10-2018.10，30万元，主持 11. 广东省高等学校优秀青年教师培养对象，2015.1-2017.12，30万元，主持 12. 广州市珠江科技新星：纳米探针在人端粒酶生物学上的基础研究：功能调控及活性检测，2013.5-2016.6，30万元，主持 13. 广东省自然科学基金：基于荧光相关光谱与适配体的均相生物传感新方法与技术研究，2011.10-2013.10，5万元，主持
论文专著

论文专著(#第一作者，*通讯作者)：

1.    Menglu Hu#, Zhiqiang Qiu#, Zirong Bi, Tian Tian, Yongzhong Jiang, and Xiaoming Zhou*, Photocontrolled crRNA activation enables robust CRISPR-Cas12a diagnostics, PNAS, 2022, doi:10.1073/pnas.2202034119.

2.    Mei Lin, Huahua Yue, Tian Tian, Erhu Xiong, Debin Zhu, Yongzhong Jiang*, and Xiaoming Zhou*, Glycerol additive boosts 100-fold sensitivity enhancement for one-pot RPA-CRISPR/Cas12a assay, Analytical Chemistry, 2022, doi:10.1021/acs.analchem.2c00616.

3.    Zi-Rong Bi, Meng-Lu Hu, Yong-Zhong Jiang, Er-Hu Xiong, Bo-Wen Shu, Si-Qi Li, Han-Wei Chen*, Xiao-Hua Chen*, Xiao-Ming Zhou*, Development of A Handheld Nano-centrifugal Device for Visual Virus Detection, Journal of Analysis and Testing, 2022, Accepted.

4.    Xin Guo#, Tian Tian#, Xinchun Deng, Yang Song, Xiaoming Zhou*, Erqun Song*, CRISPR/Cas13a assisted amplification of magnetic relaxation switching sensing for accurate detection of miRNA-21 in human serum, Analytica Chimica Acta 1209 (2022) 339853.

5.    Miao Qiu, Xiaoming Zhou*, Lei Liu*, Improved Strategies for CRISPR-Cas12-based Nucleic Acids Detection, Journal of Analysis and Testing, 2022, 6, 44-52.

6.    Mengqi Huang#, Erhu Xiong#*, Yan Wang, Menglu Hu, Huahua Yue, Tian Tian, Debin Zhu, Hong Liu, and Xiaoming Zhou*, Fast microwave heating-based one-step synthesis of DNA and RNA modified gold nanoparticles, Nature Communications, 2022, 13, 968.

7.    Menglu Hu, Debin Zhu*, Xiaoming Zhou*, M-CDC: Magnetic pull-down-assisted colorimetric method based on the CRISPR/Cas12a system, Methods, 2022, https://doi.org/10.1016/j.ymeth.2021.11.009.

8.    Tian Tian#, Zhiqiang Qiu#, Yongzhong Jiang, Debin Zhu, Xiaoming Zhou*, Exploiting the orthogonal CRISPR-Cas12a/Cas13a trans-cleavage for dual-gene virus detection using a handheld device, Biosensors and Bioelectronics 196 (2022) 113701.

9.    Huahua Yue, Bowen Shu*, Tian Tian, Erhu Xiong, Mengqi Huang, Debin Zhu, Jian Sun, Qing Liu, Shichan Wang, Yirong Li, and Xiaoming Zhou*, Droplet Cas12a Assay Enables DNA Quantifification from Unamplifified Samples at the Single-Molecule Level, Nano Letters, 2021, 21, 4643−4653.

10.  Huahua Yue, Mengqi Huang, Tian Tian, Erhu Xiong, and Xiaoming Zhou*, Advances in Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)-Based Diagnostic Assays Assisted by Micro/Nanotechnologies, ACS Nano, 2021, 15, 7848−7859.

11.  Wei Lin, Tian Tian, Yongzhong Jiang, Erhu Xiong, Debin Zhu*, Xiaoming Zhou*, A CRISPR/Cas9 eraser strategy for contamination-free PCR end-point detection, Biotechnology and Bioengineering, 2021, 118, 2053-2066.

12.  Yongzhong Jiang, Menglu Hu, An-An Liu, Yi Lin, Linlin Liu, Bo Yu, Xiaoming Zhou*, and Dai-Wen Pang*, Detection of SARS-CoV-2 by CRISPR/Cas12a-Enhanced Colorimetry, ACS Sensors, 2021, 6(3),1086-1093.

13.  Tian Tian, Bowen Shu*, Yongzhong Jiang, Miaomiao Ye, Lei Liu, Zhang Wang, Zhonghui Guo, Zeping Han, Xiaoming Zhou*, An Ultralocalized Cas13a Assay Enables Universal and Nucleic Acid Amplification-Free Single-Molecule RNA Diagnostics, ACS Nano, 2021, 15, 1167−1178.

14.  Erhu Xiong, Ling Jiang, Tian Tian, Menglu Hu, Huahua Yue, Mengqi Huang, Wei Lin, Yongzhong Jiang, Debin Zhu, and Xiaoming Zhou*, Simultaneous dual-gene diagnosis of SARS-CoV-2 based on CRISPR/Cas9-mediated lateral flow assay, Angew Chem Int Ed, 2021, 60, 5307−5315.

15.  Meng Cheng, Erhu Xiong, Tian Tian, Debin Zhu, Huai-qiang Ju, Xiaoming Zhou, A CRISPR-driven colorimetric code platform for highly accurate telomerase activity assay, Biosensors and Bioelectronics 172 (2021) 112749.

16.  Yijuan Bao#, Yongzhong Jiang#, Erhu Xiong, Tian Tian, Zhenzhen Zhang, Jing Lv, Yang Li*, Xiaoming Zhou*, CUT-LAMP: Contamination-Free Loop-Mediated Isothermal Amplification Based on CRISPR/Cas9 Cleavage, ACS Sensors, 2020, 5, 1082-1091.

17.  Menglu Hu, Chaoqun Yuan, Tian Tian, Xusheng Wang, Jian Sun, Erhu Xiong*, Xiaoming Zhou*, Single-step, salt aging-free and thiol-free freezing construction of AuNP-based bioprobes for advancing CRISPR-based diagnostics, J. Am. Chem. Soc. 2020, 142, 7506−7513.

18.  Jinjin Shen, Xiaoming Zhou, Yuanyue Shan, Huahua Yue, Ru Huang, Jiaming Hu*, and Da Xing*, Sensitive detection of a bacterial pathogen using allosteric probe-initiated catalysis and CRISPR-Cas13a amplification reaction, Nature Communications, 2020, 11(1): 1-10.

19.  Xusheng Wang, Erhu Xiong, Tian Tian, Meng Cheng, Wei Lin, Heng Wang, Guihong Zhang, Jian Sun*, and Xiaoming Zhou*, Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Lateral Flow Nucleic Acid Assay, ACS Nano, 2020, 14, 2497−2508.

20.  Chaoqun Yuan#, Tian Tian#, Jian Sun#, Menglu Hu, Xusheng Wang, Erhu Xiong, Meng Cheng, Yijuan Bao, Wei Lin, Jieming Jiang, Chengwei Yang, Qian Chen, Huang Zhang, Heng Wang, Xiran Wang, Xianbo Deng, Xiaoping Liao, Yahong Liu, Zhang Wang*, Guihong Zhang*, Xiaoming Zhou*, Universal and Naked-Eye Gene Detection Platform Based on CRISPR/Cas12a/13a System, Analytical Chemistry, 2020, 92, 4029−4037.

21.  Qian Chen, Tian Tian, Erhu Xiong, Po Wang*, and Xiaoming Zhou*, CRISPR/Cas13a Signal Amplification Linked Immunosorbent Assay for Femtomolar Protein Detection, Analytical Chemistry, 2020, 92, 573-577.

22.  Erhu Xiong, Deshuai Zhen, Ling Jiang*, and Xiaoming Zhou*, Binding-Induced 3D-Bipedal DNA Walker for Cascade Signal Amplification Detection of Thrombin Combined with Catalytic Hairpin Assembly Strategy, Analytical Chemistry, 2019, 91, 15317−15324.

23.  Yuanyue Shan, Xiaoming Zhou, Ru Huang, and Da Xing*, High-Fidelity and Rapid Quantification of miRNA Combining crRNA Programmability and CRISPR/Cas13a trans-Cleavage Activity, Analytical Chemistry, 2019, 91, 5278−5285.

24.  Chun Wu, Ke-Jia Wu, Jin-Biao Liu, Xiaoming Zhou, Chung-Hang Leung* and Dik-Lung Ma*, A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(III) complexes, Chemical Communications, 2019, 55(45): 6353-6356.

25.  Yuhui Liao, Xiaoming Zhou*, Yu Fu, and Da Xing*, Graphene Oxide as a Bifunctional Material Towards Superior RNA Protection and Extraction, ACS Appl. Mater. Interfaces, 2018, 10, 30227-30234.

26.  Hongxing Liu, Xiaoming Zhou*, Qi Shen, and Da Xing*, Paper-based electrochemiluminescence sensor for highly sensitive detection amyloid oligomerization: Toward potential diagnosis of Alzheimer’s disease, Theranostics, 2018, 8, 2289-2299.

27.  Huahua Yue, Xiaoming Zhou*, Da Xing*, Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing, Nanoscale, 2018, 10, 1063-1071.

28.  Mengqi Huang, Xiaoming Zhou*, Huiying Wang, and Da Xing*, Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Triggered Isothermal Amplification for Site-Specific Nucleic Acid Detection, Analytical Chemistry, 2018, 90, 2193-2200.

29.  Bofan Li, Xiaoming Zhou*, Hongxing Liu, Huaping Deng, Ru Huang, Da Xing*, Simultaneous Detection of Antibiotic Resistance Genes on Paper-Based Chip Using [Ru(phen)2dppz]2+ Turn-on Fluorescence Probe, ACS Appl. Mater. Interfaces, 2018, 10, 4494-4501.

30.  Yu Fu, Xiaoming Zhou* and Da Xing*, Integrated Paper-based Detection Chip with Nucleic Acid Extraction and Amplification for Automatic and Sensitive Pathogen Detection, Sensors & Actuators: B. Chemical, 2018, 261, 288-296.

31.  Ru Huang, Xiaoming Zhou*, Chunsun Zhang, Da Xing*, High-specific microRNA detection based on dual-recycling cascade reaction and nicking endonuclease signal amplification, Sensors & Actuators: B. Chemical, 2018, 264, 169-176.

32.  Meng Cheng, Xiaoming Zhou* and Da Xing*, Peptide cleavage induced assembly enables highly sensitive electrochemiluminescence detection of protease activity, Sensors & Actuators: B. Chemical, 2018, 262, 516-521.

33.  Yu Fu, Xiaoming Zhou* and Da Xing*, Lab-on-capillary: a rapid, simple and quantitative genetic analysis platform integrating nucleic acid extraction, amplification and detection, Lab on a Chip, 2017, 17, 4334-4341.

34.  Yuhui Liao, Xiaoming Zhou*, Yu Fu, and Da Xing*, Linear Ru(bpy)32+−Polymer as a Universal Probe for Sensitive Detection of Biomarkers with Controllable Electrochemiluminescence Signal-Amplifying Ratio, Analytical Chemistry, 2017, 89, 13016−13023.

35.  Huaping Deng, Xiaoming Zhou*, Qianwen Liu, Bofan Li, Hongxing Liu, Ru Huang, and Da Xing*, Paperfluidic Chip Device for Small RNA Extraction, Amplification, and Multiplexed Analysis, ACS Appl. Mater. Interfaces, 2017, 9, 41151−41158.

36.  Xiaoke Yang, Xiaoming Zhou*, Minjun Zhu, Da Xing*, Sensitive detection of Listeria monocytogenes based on highly efficient enrichment with vancomycin-conjugated brush-like magnetic nano-platforms, Biosensors and Bioelectronics, 2017, 91, 238-245.

37.  Huaping Deng, Qianwen Liu, Xin Wang, Ru Huang, Hongxing Liu, Qiumei Lin, Xiaoming Zhou* and Da Xing*, Quantum Dots-Labeled Strip Biosensor for Rapidand Sensitive Detection of MicroRNA Based on Target-Recycled Nonenzymatic Amplification Strategy, Biosensors and Bioelectronics, 2017, 87, 931–940.

38.  Ru Huang, Yuhui Liao, Xiaoming Zhou*, Yu Fu, Da Xing*, Multiplexed detection of microRNA biomarkers from tumor cells andtissues with a homogeneous nano-photon switch, Sensors & Actuators: B. Chemical, 2017, 247, 505–513.

39.  Hongxing Liu, Xiaoming Zhou*, Jinjin Shen, and Da Xing*, Sensitive Detection of Hg2+ with Switchable Electrochemiluminescence Luminophore and Disposable Bipolar Electrode, ChemElectroChem, 2017, 4, 1681–1685.

40.  Weipeng Liu, Minjun Zhu, Hongxing Liu, Jitao Wei, Xiaoming Zhou* and Da Xing*, Invading stacking primer: a trigger for high-efficiency isothermal amplification reaction with superior selectivity for detecting microRNA variants, Biosensors and Bioelectronics, 2016, 81, 309–316.

41.  Lisha Zhang, Xiaoming Zhou* and Da Xing*, Rapid and Visual Detection of Listeria monocytogenes Based on Nanoparticle Cluster Catalyzed Signal Amplification, Biosensors and Bioelectronics, 2016, 86, 1-7.

42.  Weipeng Liu, Huiheng Yu, Xiaoming Zhou* and Da Xing*, In Vitro Evaluation of CRISPR/Cas9 Function by an Electrochemiluminescent Assay, Analytical Chemistry, 2016, 88, 8369-8374.

43.  Hongxing Liu, Xiaoming Zhou*, Weipeng Liu, Xiaoke Yang, and Da Xing*, Paper-Based Bipolar Electrode Electrochemiluminescence Switch for Label-Free and Sensitive Genetic Detection of Pathogenic Bacteria, Analytical Chemistry, 2016, 88, 10191-10197.

44.  Qianwen Ding, Qiuqiang Zhan, Xiaoming Zhou, Tao Zhang* and Da Xing*, Theranostic Upconversion Nanobeacons for Tumor mRNA Ratiometric Fluorescence Detection and Imaging-Monitored Drug Delivery, Small, 2016, 12, 5944-5953.

45.  Fang Liu, Hongxing Liu,Yuhui Liao,Jitao Wei, Xiaoming Zhou* and Da Xing*, Multiplex detection and genotyping of pathogenic bacteria on paper-based biosensor with a novel universal primer mediated asymmetric PCR, Biosensors and Bioelectronics, 2015,74, 778–785.

46.  Minjun Zhu, Weipeng Liu, Hongxing Liu, Yuhui Liao, Jitao Wei, Xiaoming Zhou* and Da Xing* Construction of Fe3O4/Vancomycin/PEG Magnetic Nanocarrier for Highly Efficient Pathogen Enrichment and Gene Sensing, ACS Appl. Mater. Interfaces, 2015, 7, 12873−12881.

47.  Yuhui Liao, Yu Fu, Yunxia Wu, Ru Huang, Xiaoming Zhou* and Da Xing*, Ultrasensitive Detection of MicroRNA in Tumor Cells and Tissues via Continuous Assembly of DNA Probe, Biomacromolecules, 2015, 16, 3543−3551.

48.  Ru Huang, Yuhui Liao, Xiaoming Zhou*, Da Xing*, Toehold-mediated nonenzymatic amplification circuit on grapheme oxide fluorescence switching platform for sensitive and homogeneous microRNA detection, Analytica Chimica Acta, 2015, 888, 162-172.

49.  Xiaoming Zhou, DebinZhu, Yuhui Liao, Weipeng Liu, Hongxing Liu, Zhaokui Ma, Da Xing*, Synthesis, labelling, and bioanalytical applications of a tris (2, 2'-bipyridyl) ruthenium (II) based electrochemiluminescence probe, Nature Protocols, 2014, 9, 1146-1159.

50.  Ting Zhou, Xiaoming Zhou*, Da Xing*, Controlled release of doxorubicin from graphene oxide based charge-reversal nanocarrier, Biomaterials, 2014, 35, 4185-4194.

51.  Yuhui Liao, Ru Huang, Zhaokui Ma, Yunxia Wu, Xiaoming Zhou*, and Da Xing*, A target-triggered enzyme-free amplification strategy for sensitive detection of microRNA in tumor cells and tissues, Analytical Chemistry, 2014, 86, 4596-4604.

52.  Weipeng Liu, Xiaoming Zhou*, Da Xing*, Rapid and reliable microRNA detection by stacking hybridization on electrochemiluminescent chip system, Biosensors and Bioelectronics, 2014, 58, 388–394.

53.  Hongxing Liu, Fangfang Zhan, Fang Liu, Minjun Zhu, Xiaoming Zhou* and Da Xing*, Visual and sensitive detection of viable pathogenic bacteria by sensing of RNA markers in gold nanoparticles based paper platform, Biosensors and Bioelectronics, 2014, 62, 38–46.

54.  Yuhui Liao, Xiaoming Zhou* and Da Xing*, Quantum Dots and Graphene Oxide Fluorescent Switch Based Multivariate Testing Strategy for Reliable Detection of Listeria monocytogenes, ACS Appl. Mater. Interfaces, 2014, 6, 9988−9996.

55.  Jitao Wei, Hongxing Liu, Fang Liu, Minjun Zhu, Xiaoming Zhou*, Da Xing* Miniaturized Paper-Based Gene Sensor for Rapid and Sensitive Identification of Contagious Plant Virus, ACS Appl. Mater. Interfaces, 2014, 6, 22577−22584.

56.  Jianzhi Liu, Yongjun Hu*, Guichi Zhu, Xiaoming Zhou, Li Jia, Tao Zhang, Highly Sensitive Detection of Zearalenone in Feed Samples Using Competitive Surface-Enhanced Raman Scattering Immunoassay, Journal of Agricultural and Food Chemistry, 2014, 62, 8325-8332.

57.  Yi Long, Xiaoming Zhou*, Da Xing*, An isothermal and sensitive nucleic acids assay by target sequence recycled rolling circle amplification, Biosensors and Bioelectronics, 2013, 46, 102-107.

58.  Zhongyu Fu, Xiaoming Zhou*, Da Xing*, Sensitive colorimetric detection of Listeria monocytogenes based on isothermal gene amplification and unmodified gold nanoparticles, Methods, 2013,64, 260–266.

59.  Zhongyu Fu, Xiaoming Zhou*, Da Xing*, Rapid colorimetric gene-sensing of food pathogenic bacteria using biomodification-free gold nanoparticle, Sensors & Actuators: B. Chemical, 2013,182, 633–641.

60.  Xiao Zhu, Xiaoming Zhou, Da Xing*, Label-Free Detection of MicroRNA: Two-Step Signal Enhancement with a Hairpin-Probe-Based Graphene Fluorescence Switch and Isothermal Amplification, Chemistry A European Journal, 2013, 19, 5487–5494.

61.  Fangfang Zhan, Xiaoming Zhou, Da Xing*, Rapid and sensitive electrochemiluminescence detection of rotavirus by magnetic primer based reverse transcription-polymerase chain reaction, Analytica Chimica Acta, 2013, 761, 71-77.

62.  Xiaoming Zhou, Yuhui Liao, Da Xing*, Sensitive monitoring of RNA transcription levels using a graphene oxide fluorescence switch, Chinese Science Bulletin, 2013, 21: 2634-2639.

63.  Xiaoming Zhou, and Da Xing*, Assays for human telomerase activity: progress and prospects, Chemical Society Reviews, 2012, 41, 4643-4656.

64.  Liyun Xue, Xiaoming Zhou (co-first author), and Da Xing*, Sensitive and Homogeneous Protein Detection Based on Target- Triggered Aptamer Hairpin Switch and Nicking Enzyme Assisted Fluorescence Signal Amplification, Analytical Chemistry, 2012, 84, 3507−3513.

65.  Xiaoming Zhou, Qiang Su, Da Xing*, An electrochemiluminescent assay for high sensitive detection of mercury based on isothermal rolling circular amplification, Analytica Chimica Acta, 2012, 713, 45–49.

66.  Xiaoming Zhou, Ruixue Duan, and Da Xing*, Highly sensitive detection of protein and small molecules based on aptamer-modified electrochemiluminescence nanoprobe, Analyst, 2012, 137, 1963-1969.

67.  Xiaoming Zhou, Da Xing*, Amplified electrochemiluminescence detection of nucleic acids by hairpin probe based isothermal amplification, Analyst, 2012, 137, 4188-4192.

68.  Zhen Zhao, Xiaoming Zhou*, Ultrasensitive electrochemiluminescence detection of mercury ions based on DNA oligonucleotides and cysteamine modified gold nanoparticles probes, Sensors & Actuators: B. Chemical, 2012 (171–172) 860– 865.

69.  Zhen Zhao, Xiaoming Zhou, Da Xing*, Highly sensitive protein kinase activity assay based on electrochemiluminescence nanoprobes, Biosensors and Bioelectronics, 2012, 31, 299-304.

70.  Xiao Zhu, Xiaoming Zhou, Da Xing*, Nano-magnetic primer based electrochemiluminescence-polymerase chain reaction (NMPE-PCR) assay, Biosensors and Bioelectronics, 2012, 31, 463-468.

71.  Xiaoming Zhou, Yonghong Tang, and Da Xing*, One-Step Homogeneous Protein Detection Based on Aptamer Probe and Fluorescence Cross-Correlation Spectroscopy, Analytical Chemistry, 2011, 83, 2906–2912.

72.  Yi Long, Xiaoming Zhou, Da Xing*, Sensitive and isothermal electrochemiluminescence gene-sensing of Listeria monocytogenes with hyperbranching rolling circle amplification technology, Biosensors and Bioelectronics, 2011, 26, 2897-2904.

73.  Xiao Zhu, Xiaoming Zhou, Da Xing*, Ultrasensitive and Selective Detection of Mercury (II) in Aqueous Solution by Polymerase Assisted Fluorescence Amplification, Biosensors and Bioelectronics, 2011, 26, 2666-2669.

74.  Ruixue Duan, Xiaoming Zhou (co-first author), Da Xing*, Electrochemiluminescence Biobarcode Method Based on Cysteamine-Gold Nanoparticle Conjugates, Analytical Chemistry, 2010, 82, 3099-3103.

75.  Jie Wei, Xiaoming Zhou (co-first author), Da Xing*, Rapid and sensitive detection of vibrio parahaemolyticus in sea foods by electrochemiluminescence polymerase chain reaction method, Food Chemistry, 2010, 123, 852-858.

76.  Liyun Xue, Xiaoming Zhou and Da Xing*, Highly sensitive protein detection based on aptamer probe and isothermal nicking enzyme assisted fluorescence signal amplification, Chemical Communications, 2010, 46, 7373–7375.

77.  Qiang Li, Xiaoming Zhou, Da Xing*, Rapid and highly sensitive detection of mercury ion (Hg2+) by magnetic beads-based electrochemiluminescence assay, Biosensors and Bioelectronics, 2010, 26, 859-862.

78.  Qiang Su, Da Xing*, Xiaoming Zhou, Magnetic beads based rolling circle amplification–electrochemiluminescence assay for highly sensitive detection of point mutation, Biosensors and Bioelectronics, 2010, 25, 1615-1621.

79.  Debin Zhu, Xiaoming Zhou, Da Xing*, A new kind of aptamer-based immunomagnetic electrochemiluminescence assay for quantitative detection of protein, Biosensors and Bioelectronics, 2010, 26, 285-288.

80.  Xiaoming Zhou, Da Xing*, Debin Zhu, Li Jia, Magnetic bead and nanoparticle based electrochemiluminescence amplification assay for direct and sensitive measuring of telomerase activity, Analytical Chemistry, 2009, 81, 255-261.

81.  Xiaoming Zhou, Da Xing*, Yonghong Tang, and Wei R. Chen, PCR-Free Detection of Genetically Modified Organisms Using Magnetic Capture Technology and Fluorescence Cross-Correlation Spectroscopy, PLoS One, 2009, 4, e8074.

82.  Huijuan Zhou, Da Xing*, Debin Zhu, and Xiaoming Zhou, Rapid and sensitive detection of point mutation by DNA ligase-based electrochemiluminescence assay, Talanta, 2009, 78, 1253-1258.

83.  Xiaoming Zhou, Da Xing*, Debin Zhu and Li Jia, Magnetic beads-based electrochemiluminescence assay for rapid and sensitive detection of telomerase activity, Electrochemistry Communications, 2008, 10, 564-567.

84.  Xiaoming Zhou, Da Xing*, Debin Zhu, Yabing Tang, and Li Jia, Development and application of a capillary electrophoresis- electrochemiluminescent method for the analysis of enrofloxacin and its metabolite ciprofloxacin in milk, Talanta, 2008, 75, 1300–1306.

85.  Jie Wei, Xiaoming Zhou*, An improved electrochemiluminescence polymerase chain reaction method for the detection of Fusarium wilts, Chinese Chemical Letters, 2008, 19, 959–961.

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